What is Arginine and Is It Essential?

Answers: What is Arginine and Is It Essential?

I read that the amino acid arginine is as important to cats as taurine, but I have never heard of it. Is it true that a cat can get really sick from eating just one meal that has no arginine in it? If I feed a raw diet, is this an amino acid I should worry about or supplement?
Amino acids are the building blocks that make up proteins. There are 20 different amino acids that commonly make up proteins, 11 of which are essential for cats.¹ An amino acid is considered essential if the animal either cannot make it, or make enough of it on its own, and therefore must obtain it directly from food sources. Arginine is considered an essential amino acid for most mammals, including the cat.²
It is indeed true that eating just one meal deficient in arginine can make a cat very sick. Research has shown that cats fed a diet specifically formulated to be deficient in arginine exhibit signs of ammonia toxicity which include drooling, vomiting, lethargy and even convulsions within hours after consuming the diet.³ As a meal is digested, protein is broken down, producing by-products such as ammonia. Cats require arginine to make enzymes that the liver uses to remove these by-products from the body. When ammonia is not cleared, it builds up and results in these signs of toxicity.
Your cat's need for arginine shouldn't worry you, though. According to the National Research Council, the recommended minimum daily allowance of arginine is 190 mg per kilogram of body weight. Being that most cats weigh approximately 10 pounds or 4.5 kilograms at ideal body condition, this would mean that the general requirement would be about 855 mg of arginine per day.
Getting enough arginine in the diet is not a problem as pretty much every protein source from beef to chicken to rabbit has plenty of arginine. An ounce of raw chicken has about 360 mg of arginine, an ounce of raw beef about 410 mg and an ounce of raw rabbit about 350 mg. An average cat eating a raw meat diet will eat somewhere between four and six ounces of raw food a day, so your cat will get enough arginine.
Note: The Feline Nutrition Education Society provides feline health and nutrition information as a public service. Diagnosis and treatment of specific conditions should always be in consultation with your own veterinarian. The Feline Nutrition Education Society disclaims all warranties and liability related to the veterinary advice and information provided on this site.
If you have a question, please send it to 95ba79c1cbbebf967bc6bac2c5cdc893bac7ccd0becbcc99bfbec5c2c7be86c7cecdcbc2cdc2c8c787c8cbc07b97bac7ccd0becbcc99bfbec5c2c7be86c7cecdcbc2cdc2c8c787c8cbc09588ba9787 w7r2Q7nykkytvX3qt0G2oar9uoS5eBWa caesar This page part is protected against spam bots and web crawlers. In order to be displayed you need to enable Javascript in your browser, and then reload the page. while we cannot answer questions individually, if your question would be helpful to others, we may post it in Answers.
Dr. Elisa Katz, DVM, is a graduate of Ohio State University and is the owner of Natural Pet Animal Hospital in Bourbonnais, Illinois. She practices holistic and integrative medicine focusing on proper diet and nutrition. Dr. Katz shares her home with four kitties and one dog.
  1. Kathy L Gross, et al, "Nutrients," Small Animal Clinical Nutrition, 4th ed. Walsworth Publishing Company, 2000, 48-51.
  2. National Research Council Ad Hoc Committee, "Nutrient Requirements of Dogs and Cats," National Academies Press, Washington DC, 2006, 112.
  3. James G Morris, "Nutritional and Metabolic Responses to Arginine Deficiency in Carnivores," Journal of Nutrition 115, 1985, 524-531.
  4. RO Ball, et al, "Nutritional Consequences of Interspecies Differences in Arginine and Lysine Metabolism," Journal of Nutrition 137, 2007, 1626S-1641S.
  5. National Research Council Ad Hoc Committee, "Nutrient Requirements of Dogs and Cats," National Academies Press, Washington DC, 2006, 366.
  6. "Foods Highest in Arginine," NutritionData.com, 2011.





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